In our previous study [20], AUC for different aPL and APS (either thrombotic or obstetric) varied from 0.88 for IgG aCL to 0.55 for IgM anti-β2GPI, while Otomo et al. determined AUC (for the revised Sydney criteria) to be 0.688 [31]. This evidence concerns the gene CD40LG and autoimmune polyendocrinopathy.