In addition, treatment with BRAF inhibitors can lead to the induction of second primary cancers, including squamous cell carcinomas of the skin and new primary BRAF wild-type melanomas; other side effects are nausea, diarrhea, arthralgias, nonspecific skin rashes, fatigue, alopecia, and photosensitivity [62–64]. This evidence concerns the gene BRAF and melanoma.