A system composed of methacrylate-f-CD to solubilize the TGF-β inhibitor and liposomes loaded with a biodegradable crosslinking polymer and IL-2 cytokine was developed to sustain cytokines release to the tumor microenvironment and induces antitumor immune responses in a B16/B6 mouse. This evidence concerns the gene TGFB1 and neoplasm.