Immunotherapy has also been applied for MEL therapy; immunotherapy employs cytokines that stimulate the patient's immune system to fight cancer, such as interleukin (IL), IL-2, IL-5, IL-7, and IL-21, interferon-α (INF-α), and granulocyte macrophage colony–stimulating factor (GM-CSF) [59]. This evidence concerns the gene IL2 and cancer.