In conclusion, siRNA targeting of B7-H4 effectively suppressed the proliferation, invasion, and migration of LOVO cells by inhibiting the effect of CXCL12/CXCR4 and the phosphorylation of JAK2/STAT3 on increasing the metastatic potential of colorectal carcinoma. The gene discussed is VTCN1; the disease is colorectal carcinoma.