Patients with venous thromboembolism demonstrate increased levels of proinflammatory cytokines including interleukin-6, interleukin-8, and TNF-alpha [6–8] and the formation of blood clots has been shown to lead to thrombus fragmentation and generation of proinflammatory fibrin breakdown products [9]. The gene discussed is CXCL8; the disease is venous thromboembolism.