AKT1 and Insulin resistance: Interestingly, Padiya et al. [59] showed that administration of freshly prepared homogenate of garlic, which have been shown to generate H2S after interaction within cellular proteins, can activate myocardial nuclear-factor-E2-related factor-2 (Nrf2) through PI3K/AKT pathway and attenuate cardiac hypertrophy and oxidative stress through augmentation of antioxidant defense system in fructose-fed insulin resistance rats.