Interestingly, Padiya et al.'s study [59] showed that administration of raw garlic homogenate in insulin resistance fructose fed rat activated myocardial Nrf2 by increasing H2S level and activating PI3K/AKT pathway and attenuated cardiac hypertrophy and oxidative stress through augmentation of antioxidant defense system. This evidence concerns the gene AKT1 and cardiac hypertrophy.