NOS2 and metabolic dysfunction-associated steatotic liver disease: Since increased oxidative/nitrosative stress and inflammation are known to trigger increased endocannabinoid production or impair endocannabinoid inactivation [55–57], it is likely that endocannabinoids contribute to HFD-induced liver damage in present experimental model of NAFLD by promoting expression of iNOS in hepatic parenchymal cells and/or peripheral blood mononuclear cells through the activation of CB1 receptors [58–61].