One of the crucial events in cancer disease is the metastasis formation, which is considered a complex multistep event with sequential molecular and cellular events including EMT, migration and invasion, blood vessel intra- and extravasation, survival, and growth in a new tissue environment [79], in which the mutual interaction of oxidative stress/ROS and TGF-β may play a role in almost all stages described. This evidence concerns the gene TGFB1 and cancer.