Exogenous H2S can induce/enhance autophagy to inhibit the proliferation of colon epithelial cells or reduce hyperglycemia-induced matrix remodeling by glomerular endothelial cells via signaling pathways of AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) [112, 113]. The gene discussed is MTOR; the disease is Hyperglycemia.