AGT and hypertensive disorder: Exogenous H2S attenuated angiotensin II-induced hypertension, cardiac fibrosis, and oxidative stress in rats [52]. In vitro study also confirmed the antiangiotensin II effect of H2S. For instance, NaHS (50–100 μmol/L) inhibited the cardiac fibroblasts proliferation induced by 10% fetal bovine serum and angiotensin II [53].