ITGAM and hyperinsulinemic hypoglycemia, familial, 4: Ge et al. also used a murine cardiac transplant model and revealed that donor IL-6 deficiency significantly increased the infiltration of two MDSC subsets, CD11b+Gr1−low and CD11b+Gr1−int, with strong immunosuppression activity in the transplanted graft, which resulted in a dramatic increase in the frequency of CD11b+Gr1−low cells and a significant decrease of the frequency of CD11b+Gr1−high and CD4−CD8−NK1.1+ cells in the recipient's spleen.