To further corroborate the role of PRMT5 in CRC cell proliferation, three different small interfering RNAs (siRNAs) against human PRMT5 (Supplementary Figure 1A) was used to knockdown PRMT5 in four human CRC cell lines, HCT116, SW480, SW620 and LS-174T. Here, PRMT5 is linked to colorectal carcinoma.