The significant higher levels of VEGF found in the pleural exudates of patients with malignant mesothelioma compared with patients with non malignant pleural disease and the detection of a significant inverse correlation between serum VEGF and malignant mesothelioma patient survival confirm VEGF as an important mediator of angiogenesis [123]. The gene discussed is VEGFA; the disease is malignant mesothelioma.