The CCDC6-RET fusion kinase in patient 1 occurred at a novel breakpoint at CCDC6 intron 2 and RET intron 10 from a chromosome 10 inversion event, which differs from the CCDC6-RET fusion kinase breakpoints in thyroid cancer and lung cancer that fused CCDC6 exon 1 to RET exon 12-20 [9]. The gene discussed is RET; the disease is thyroid gland carcinoma.