Large DCIS cases were found to have fewer copy number gains of MYC (40.9 % of large and 66.6 % of small DCIS) and of ZNF217 (27.2 % of large and 47.6 % of small), and in cases with an above-median Ki-67 index, large DCIS lesions showed fewer amplifications compared with small lesions [68]. This evidence concerns the gene MYC and ductal breast carcinoma in situ.