NOTCH1 and ductal breast carcinoma in situ: Translocations of two genes previously associated with increased oncogenic activity [80], MAST2 and NOTCH1, were identified by FISH in one study in 4 out of 115 (3.5 %) and 2 out of 115 (1.7 %) mixed DCIS cases, respectively, but these translocations were not observed in 170 cases of pure DCIS [81].