Copy number alterations of CCNE1 (19q12) and AURKA (20q13) have been reported to occur exclusively in high-grade DCIS [47], while the 11q13 amplicon, frequently present in high-grade DCIS, contains the known oncogene CCND1 [32] (Fig. 1). The gene discussed is CCNE1; the disease is ductal breast carcinoma in situ.