TRIM8 and central nervous system cancer: In tumor tissue glioma, median TRIM8 relative expressions were 0.49 in GBM (IQR: 0.30-0.82), 0.81 in WHO grade III (IQR: 0.37-2.32) and 2.61 in WHO grade I-II (IQR:1.52-6.14) glioma (Fig. 1a).