TRIM8 and central nervous system cancer: We next examined the transcriptional profile of TRIM8 in an independent cohort, i.e. the TCGA cohort, detecting a significant lower expression of TRIM8 in grade III glioma (Median:0.65, IQR:0.32-1.23) as compared with grade II glioma (Median: 1.05, IQR 0.63-1.79) (Fig. 1c).