We presented experimental evidences showing that i) TRIM8 expression level is significantly decreased in glioma and is inversely associated with glioma WHO grades in both our own cases collection and in the independent TCGA glioma cohort, ii) lower TRIM8 tissues expression level is an independent predictor of risk of death in WHO grade III tumours (TCGA dataset), and iii) the overexpression of TRIM8 suppresses cell growth and induces a significant reduction of clonogenic potential in both U87MG glioblasto ma and patient’s primary glioma cell lines. This evidence concerns the gene TRIM8 and neoplasm.