Accordingly, while chow-fed DJ-1 KO mice did not differ from control littermates in terms of glucose homeostasis up to 5 months of age (Supplementary Fig. 8), when subject to a chronic HFD, DJ-1 KO mice, particularly females, were protected from HFD-induced obesity (Fig. 6g and Supplementary Fig. 9). Here, PARK7 is linked to obesity due to melanocortin 4 receptor deficiency.