IL22 and myeloid sarcoma: In the brain of control subjects, the IL-22/IL-22R1 colocalization seemed to be slightly more expressed in the GM than in the WM (Fig. 3a, b), whereas in MS, it was clearly stronger in the plaques, either in the WM (Fig. 4a, b) or the subpial GM (Fig. 4c, d), than in the normal appearing white matter (NAWM) (Fig. 4a, b).