Next, we found that the supernatant of SEB-stimulated PBMC of 74 MS patients secreted a higher amount of IL-22 than of 32 HC (p = 0.0436, Fig. 1d), a finding which was ascribable to the active category of MS patients (active versus HC: p = 0.0048, active versus inactive: p = 0.0216, Fig. 1e). Here, IL22 is linked to myeloid sarcoma.