Given the significant increase in serum IL-1ß levels at 49 weeks and the equally moderate elevation in caspase-1 activity at 8, 27 and 49 weeks, we cannot rule out that mechanisms other than inflammasome-mediated caspase-1 contribute to the IL-1ß increase in the advanced stage of NASH in our model. The gene discussed is CASP1; the disease is metabolic dysfunction-associated steatohepatitis.