In addition, adipose tissue in obesity secrets elevated level of proinflammatory adipokines such as leptin, tumor necrosis factor-α (TNF-α) and interleukins (ILs) but lowered level of anti-inflammatory cytokine such as adiponectin, resulting in metabolic disorder and chronic inflammation of the body [5, 6]. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.