Hsd11b2 knockout rats demonstrate many of the symptoms of SAME, including reduced size, polydipsia, polyuria, and salt-sensitive hypertension, which were previously observed in an Hsd11b2 knockout mouse generated by standard gene–targeting techniques.12–17 Although rats did not develop the profound salt wasting and progressive loss of renal medulla seen in older knockout mice, significant renal damage was observed at 9 months of age. Here, HSD11B2 is linked to Polyuria.