ANGPTL8 and type 2 diabetes mellitus: Adjusting for total cholesterol, triglyceride, LDL, HDL, systolic, diastolic blood pressure + Model 3 further attenuated the association showing that subjects in the highest tertiles of betatrophin had higher odds of having T2D (OR = 6.15, 95% CI = 3.15 – 12.01) (p-trend <0.0001).