The APOE locus is also strongly associated with neurological disease (particularly Alzheimer’s disease) (Naj et al., 2014; Wang et al., 2014), cardiac, metabolic, and vascular diseases (Maxwell et al., 2013; Hellwege et al., 2014), plasma C-reactive protein levels (Ellis et al., 2014; Schick et al., 2014), and, in a recent study, nonpathological cognitive aging (Davies et al., 2014). The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.