LILRB2 and early-onset autosomal dominant Alzheimer disease: In addition to acting as a receptor for NogoA, PirB and its human ortholog leukocyte immunoglobulin-like receptor, subfamily B, member 2 (LILRB2) are receptors for beta amyloid; interaction of beta amyloid with PirB/LILRB2 impairs synaptic plasticity and enhances synaptic loss, suggesting a contribution to Alzheimer’s disease pathology [15].