For example, population-based longitudinal study by Holvik et al. found that there was no association between plasma osteocalcin level and cardiovascular diseases (CVD) in younger-old subjects (65–74 years), but a higher plasma osteocalcin concentration was associated with a reduced risk of CVD in older-old men (≥75 years) while with an increased risk of CVD in older-old women (≥75 years) [13]. The gene discussed is BGLAP; the disease is cardiovascular disorder.