EGFR and non-small cell lung carcinoma: 7 eligible studies reported association between BIM deletion polymorphism and PFS in TKI treated solid cancer patients were enrolled in our study and the pooled results showed a significant association between them only in EGFR-mutated NSCLC patients (univariate analysis: Ph = 0.164, HR = 2.000, 95%CI = 1.629–2.455; multivariate analysis: Ph = 0.580, HR = 2.194, 95%CI = 1.710–2.814), not in HCC subgroup (univariate analysis: HR = 0.720, 95%CI = 0.364–1.422; multivariate analysis: HR = 0.866, 95%CI = 0.408–1.837) (Table 3 and Fig. 3).