Based on our experiments, we indicated that different types of cyto-chemokines are involved in the crosstalk between hAT-MSCs and BTICs (CXCR4/SDF-1, CCR5/RANTES, IL6R/IL-6 and IL8R/IL8 in medulloblastoma-BTICs and AT/RT-BTICs; CXCR4/SDF-1, IL6R/IL-6, IL8R/IL-8 and IGF1R/IGF-1 in glioblastoma-BTICs). The gene discussed is CCL5; the disease is glioblastoma.