Despite the small numbers in these rare lung cancer subtypes, SNV calling using the OncoMap database revealed previously undescribed SNV in FGFR1, CDKN2A, RB1, JAK3, and CTNNB1 for the large-cell type, a BRAF mutation for carcinoid, and an AKT1 mutation for adenosquamous carcinoma. The gene discussed is CTNNB1; the disease is lung cancer.