CD4 and HIV infectious disease: Consistent with the only other study that has examined VRC in pediatric HIV infection, in a small study of 8 infected children [35], here we show that VRC is also related to pediatric disease outcome (Fig 1), being on average 15% lower in slow progressors compared to rapid progressors, and correlating with CD4 count at 5yrs and 7.5yrs age, despite the VRC assays in the slow progressor children being determined on average 7.5yrs after transmission.