As displayed in Fig 6B, levels of PTX3 in naïve SSc sera (2.60 ± 0.43 ng/ml) were significantly higher than in control sera (1.09 ± 0.22 ng/ml, p = 0.008) and CYC-treated SSc sera (1.17 ± 0.16 ng/ml, p = 0.002). Here, PTX3 is linked to systemic sclerosis.