Knowledge of the genes controlling development of DP and matrix come from studies of the morphogenesis and cycle of HF of mice and human[24–28], It involves a series of signaling between the matrix and the dermal papill, such as Wnt/beta-catenin, EDA/EDAR/NF-κB, Noggin/Lef-1, Ctgf/Ccn2, Shh, BMP-2/4/7, Dkk1/Dkk4 and EGF[4, 29]. This evidence concerns the gene CCN2 and hydrops fetalis.