PTEN and neoplasm: ML100 has also been shown to suppress the growth of colon tumor cells lacking either oncogenic beta catenin expression (AID 818) or the tumor suppressor PTEN (AID 827); it also inhibits P450 CYP1A2 (AID 1851) and the assembly of the perinucleolar compartment (PNC) (AID 2417); and it activates the apoptotic arm of the UPR in CHO cells (AID 449763).