DCTPP1 and neoplasm: It has been reported that breast cancer stem cells (CSCs) could be enriched in suspension cultures as mammospheres,31 which is used for functional characterization of stem-cell like population with vigorously tumor-initiating potential.32 To determine the possible involvement of DCTPP1 in maintaining CSC-like property, mammosphere formation capacity was determined in DCTPP1 knockdown and overexpressed cell lines in parallel accordingly.33 Notably, DCTPP1 silencing in MCF-7 resulted in a significant reduction in both sphere size and sphere forming number (Figure 3a).