It is worth noting that the global DNA hypomethylation was first revealed in 198350 and is the most common molecular lesion in cancer cells51 as well as tumor-initiating cells.52 In addition, in the previous28 and present studies we found that DCTPP1 was inclined to accumulate in the nucleus of cancer cells compared with the paired adjacent tissue cells in multiple carcinomas, which facilitated the regulation of nucleotide concentration. Here, DCTPP1 is linked to cancer.