CDH1 and neoplasm: The latter is kept at a low level through a destruction complex;15 thus, it may be correlated with tumor grade and stage.21, 22 Some evidence shows that the nuclear accumulation of β-catenin is correlated with the expression of CD44 the CSCs markers.23 This indicates that activation of β-catenin is required for the sustention of CSC-like traits generated by loss of E-cadherin expression first.