CDH1 and neoplasm: IHC scoring was determined by multiplying the staining intensity by the percentage of positive tumor cells.34, 35 In addition, we found that E-cadherin (total) expression in lung cancers correlated inversely with nuclear β-catenin expression (P<0.01; Figure 1b), whereas no correlation was observed between the expression of nuclear E-cadherin and nuclear β-catenin (Figure 1c).