CDH1 and lung cancer: Some studies suggest that loss of E-cadherin expression does not induce Wnt signaling, whereas in other studies a role of E-cadherin in modulation of Wnt-dependent gene expression has been suggested.48, 49 In view of the close association between E-cadherin and β-catenin, we speculate that the nuclear localization of E-cadherin is related to β-catenin abnormalities in human lung cancer.