Furthermore, nuclear E-cadherin expression was more significantly inversely correlated with CD133 expression (P<0.005) than E-cadherin (total) expression (P<0.05), suggesting that lung cancer defined by nuclear E-cadherinLow/nuclear β-cateninHigh/CD133High biomarkers has superior prognostic value over total E-cadherinLow/nuclear β-cateninHigh/CD133High. This evidence concerns the gene PROM1 and lung cancer.