Subcutaneous inoculation of PC-3 prostate cancer cells overexpressing either Pim-1 or Pim-2 into immunodeficient mice has previously been shown to result in larger tumors [18], but comparable data on Pim-3 has been lacking as also direct evidence for the ability of Pim kinases to contribute to formation of metastases. The gene discussed is PIM3; the disease is Familial prostate cancer.