Comparison of phospho-CXCR4 signals to the average CXCR4 signals in each tumor revealed that both Pim-1 and Pim-3 had significantly increased the relative amounts of phospho-CXCR4, while Pim inhibition by DHPCC-9 had decreased it even below the level observed in the mock-transfected samples (Fig 5F). Here, PIM3 is linked to neoplasm.