Overexpression of GLUT2 by neuroblastoma cells in vitro has been shown to accentuate the inhibition of AMPK phosphorylation induced by glucose while AMPK stimulation by cytoglucopenia was attenuated.26 These findings indicate that AMPK inhibition by glucose may be dependent on GLUT2 glucose sensing. The gene discussed is PRKAA1; the disease is neuroblastoma.