We have identified NFKB1-94ins/del ATTG polymorphism is associated with increased CAD risk in Chinese Uygur population, and it is also associated with IL-6 levels in SAP cases, indicating the NFKB1-94ins/del ATTG polymorphism may affect CAD risk by modulating the expression of IL-6. The gene discussed is NFKB1; the disease is coronary artery disorder.