This association remains significant after adjustment for age, sex, smoking, BMI, hypertension, diabetes, glucose, TG, TC, HDL, and LDL, indicating the association of del/del genotype with CAD risk may be in part mediated by its impact on plasma IL-6 level which may provide a mechanistic link between NFKB1 polymorphism and CAD susceptibility in Chinese Uygur population. The gene discussed is NFKB1; the disease is diabetes mellitus.