SMARCA4 and cancer: For example, Brg1 is one of the most commonly mutated subunits across cancer, occurring at a frequency of about 3% in all cancers and arising regularly in non-small cell lung carcinoma (NSCLC), Burkitts lymphoma and medulloblastoma, while also occurring in melanoma, pancreatic adenocarcinoma, ovarian clear cell carcinoma and other tumor types [110,112].