Indeed, treatment with A1-A1 efficiently reduced thrombus size in vivo in the presence of chronic autoimmune anti-β2GPI antibody in lupus-prone (NZW3BXSB)F1 male mice as well as in wild-type mice after infusion with anti-β2GPI antibodies [121]. The gene discussed is APOH; the disease is systemic lupus erythematosus.