ANXA5 and autoimmune polyendocrinopathy: Nevertheless, HCQ is currently catalysing much attention in APS: an ongoing study is assessing the effect of HCQ on Annexin A5 resistance assay in aPL patients with or without SLE; a randomized controlled trial promoted by the international research organization APS ACTION is evaluating HCQ in the primary prevention of thrombosis in aPL asymptomatic carriers at five-year follow-up [61].