Regarding clinical data, McCormick et al. (2014) have recently shown that chronic DPP-4 inhibition with sitagliptin 100 mg/day for 4 weeks protected against ischemic left ventricular dysfunction during dobutamine stress in patients with T2DM (19 patients) and coronary artery disease, possibly by GLP-1-mediated cardioprotection on ischemic regional wall segments [270]. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.