In another experimental study, Abd El Motteleb and Elshazly (2013) described a protective effect of sitagliptin against L-NAME induced hypertensive nephropathy, related to increased levels of GLP-1, upregulation of GLP-1R, and consequent overexpression of eNOS and increased serum NO levels, together with improvement of redox status [259]. The gene discussed is GLP1R; the disease is hypertensive nephropathy.