The SAVOR-TIMI 53 (saxagliptin) and EXAMINE (alogliptin) trials enrolled 16,492 and 5,380 patients over a median of 2.1 and 1.5 years, respectively, and concluded that there was no difference between the DPP-4 inhibitor treated and placebo groups with regard to pancreatitis or pancreatic cancer [225, 226]. Here, DPP4 is linked to pancreatic neoplasm.