Likewise, in 2004 Infante et al. identified statistical epistasis between interleukin-6 (IL-6) and interleukin-10 (IL-10) associated with decreased risk for Alzheimer's disease based on previous evidence that patients with Alzheimer's disease produce more proinflammatory interleukin-6 and less anti-inflammatory interleukin-10 [64]. The gene discussed is IL6; the disease is early-onset autosomal dominant Alzheimer disease.