Neurodegenerative diseases are affected by factors such as stimulating nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in the antioxidant system, sirtuin and forkhead box O (FOXO) transcription factors, and chaperones and neurotrophic factors and by inhibiting acetylcholinesterase (AChE) activity [9, 10]. This evidence concerns the gene ACHE and neurodegenerative disease.