A recent study revealed that the bark extract of E. ulmoides prevents neurodegenerative diseases such as AD by modulating the regulation of cleaved poly (ADP ribose) polymerase (PARP), cleaved caspase 3, Bcl-2, and Bcl-xL via inhibition of JNK, p38 MAPK, ERK1/2, and PI3K/AKT signaling in H2O2-treated human SH-SY5Y neuroblastoma cells [79]. The gene discussed is MAPK3; the disease is neuroblastoma.