Moreover nanoencapsulated curcumin alleviates Aβ (1–42)-induced cognitive impairment in rats by recovering BDNF levels and the AKT/GSK-3 β signaling pathway in astrocytes and microglial cells, thus leading to modulation of tau hyperphosphorylation along with an increase in hippocampal synaptophysin levels [119]. This evidence concerns the gene BDNF and Cognitive impairment.