Huperzine A attenuates cognitive defects in streptozotocin-induced diabetic rats by increasing the levels of ChAT, BDNF, SOD, glutathione peroxidase, and catalase while simultaneously inhibiting AChE, MDA, CAT, NF-κB, TNF-α, IL-1β, IL-6, and caspase-3 [160]. The gene discussed is BDNF; the disease is Cognitive impairment.