In multivariate analysis with HIF1α, IL1β, VEGF-A, IL8, mild anemia, and M status as explanatory variables, HIF1α (b = 0.61; partial r = 0.66, p < 0.001), IL1β (b = 0.23; partial r = 0.45, p = 0.001), and mild anemia (b = 0.11; partial r = 0.29, p = 0.043) were found to be independent predictors of tumor Nampt/PBEF/visfatin, explaining 70% in its variability (coefficient of determination R2 = 0.703; F = 37.1, p < 0.0001; constant = −0.03). This evidence concerns the gene HIF1A and neoplasm.