Compare to mean expression in nontumor tissue, Nampt/PBEF/visfatin expression in tumors was significantly higher in all disease stages except for stage I. It did not differ significantly with respect to local tumor progression but was higher in N2 than N1 cancers (2-fold upregulation (1.1–3.7), p = 0.029) and in M1 than M0 cancers (2.7-fold (1.3–5.3), p = 0.006). Here, NAMPT is linked to neoplasm.