All 20 LS-associated ovarian carcinomas did not show mutations on TP53, KRAS (exon 2), or BRAF (V600E), while, in sporadic ovarian carcinomas, TP53 was often abnormal (overexpressed or completely missing) and KRAS (exon 2) mutations occurred with a frequency of 8%. The gene discussed is BRAF; the disease is ovarian carcinoma.