BAX and colon adenocarcinoma: In fact, the less differentiated SW480 cells (from a moderately differentiated colon adenocarcinoma, grade IV Duke B) showed a more pronounced susceptibility to VK1 action due to a more marked antiproliferative effect, an increased Bax/Bcl-2 ratio persisting up to 72 h, and a significant increase in the phosphorylation of ERK 1/2 starting from low VK1 concentrations in comparison to the more differentiated HT-29 and Caco-2 cell lines.