ERBB2 overexpressing BT474 and MDA-MB-453 BC cells revealed in a further study that treatment with betulinic acid in the range of 1–10 μmol/L resulted in a decrease of Sp1, 3, and 4, and consequently in a decrease of YY1 promoter activity as well as a decrease in ERBB2. The gene discussed is ERBB2; the disease is breast cancer.