It has been proposed that the “way” tumor cells die, also as a consequence of chemotherapy, is crucial for the development of an efficient adaptive immune response (immunogenic cell death), since factors released from dying cells (e.g., ATP, calreticulin, or high-mobility group box 1, HMGB1, protein) prime tumor-infiltrating dendritic cells for an efficient Ag presentation to CD8+ T lymphocytes. The gene discussed is CALR; the disease is neoplasm.