In established solid tumors, TAMs contribute to angiogenesis, tumor invasion, and metastasis by producing proangiogenic factors such as vascular endothelial growth factor (VEGF)-A, epidermal growth factor (EGF), and IL-8, and proteases such as cathepsins, serine proteases, and matrix metalloproteinases (MMPs) (18). Here, EGF is linked to neoplasm.