Indeed, the administration of amphetamine-related compounds to rodents resembles some alterations related to mania [1] such as increase in dopamine (DA) neurotransmission with consequent hyperlocomotion, oxidative imbalance, and mitochondrial dysfunction, and decrease in brain derived neurotrophic factor (BDNF) in putative brain areas related to BD pathophysiology, namely, prefrontal cortex (PFC), hippocampus (HC), and striatum (ST) [9, 14, 15]. The gene discussed is BDNF; the disease is Behcet disease.