Initially, we investigated whether patients with severe allergy to peanuts (PA-group), patients sensitized to peanuts (PS-group) and healthy control subjects (C-group) could be discriminated based on X-variables that included the SPT (to peanut, soy and birch), total and specific (ISAC) IgE levels and basophil activation. The gene discussed is IGHE; the disease is Allergy.