Genetic inactivation of p53 rescued the erythroid phenotype: the erythroid differentiation defect was restored in Rps14−/+p53−/+ mice.22 This murine model shows that haploinsufficiency of Rps14 is sufficient to recapitulate the erythroid and megakaryocytic phenotype observed in the 5q- syndrome. The gene discussed is RPS14; the disease is Down syndrome.